Self-Assembled Poly(butadiene)-b-poly(ethylene oxide) Polymersomes as Paclitaxel Carriers
نویسندگان
چکیده
منابع مشابه
Paclitaxel-Loaded Polymersomes for Enhanced Intraperitoneal Chemotherapy.
Peritoneal carcinomatosis is present in more than 60% of gastric cancer, 40% of ovarian cancer, and 35% of colon cancer patients. It is the second most common cause of cancer-related mortality, with a median survival of 1 to 3 months. Cytoreductive surgery combined with intraperitoneal chemotherapy is the current clinical treatment, but achieving curative drug accumulation and penetration in pe...
متن کاملNanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair
To repair complexly shaped tissue defects, an injectable cell carrier is desirable to achieve an accurate fit and to minimize surgical intervention. However, the injectable carriers available at present have limitations, and are not used clinically for cartilage regeneration. Here, we report nanofibrous hollow microspheres self-assembled from star-shaped biodegradable polymers as an injectable ...
متن کاملSelf-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers.
This work investigates a new type of polyelectrolyte complex nanocarrier composed of hyaluronic acid (HA) and protamine (PROT). Small (approximately 60 nm) and negatively charged nanoparticles (NPs) with a polydispersity index of less than 0.2 were obtained with properties that were dependent on the mixing ratio, concentration of polyelectrolytes and molecular weight of HA. Salmon calcitonin (s...
متن کاملNear-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging.
We demonstrate that synthetic soft materials can extend the utility of natural vesicles, from predominantly hydrophilic reservoirs to functional colloidal carriers that facilitate the biomedical application of large aqueous-insoluble compounds. Near-infrared (NIR)-emissive polymersomes (50-nm- to 50-microm-diameter polymer vesicles) were generated through cooperative self assembly of amphiphili...
متن کاملMicelles of polybutadiene-b-poly(ethylene oxide) in methanol, cyclohexane, and methanol + cyclohexane.
We have studied the self-assembly of a polybutadiene-b-poly(ethylene oxide) diblock copolymer in methanol, in cyclohexane, and in the partially miscible binary mixture of methanol + cyclohexane. Molecular probe experiments indicated that PB(89)-b-PEO(132) (subscripts indicate the number of monomers in each block) forms micelles with PEO cores and PB coronas in pure cyclohexane and micelles with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biotechnology Progress
سال: 2007
ISSN: 8756-7938
DOI: 10.1021/bp060208+